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Mendeley readers
Attention Score in Context
| Title |
Different miRNA expression profiles between human breast cancer tumors and serum
|
|---|---|
| Published in |
Frontiers in Genetics, May 2014
|
| DOI | 10.3389/fgene.2014.00149 |
| Pubmed ID | |
| Authors |
Jie Zhu, Zhibao Zheng, Jia Wang, Jinhua Sun, Pan Wang, Xianying Cheng, Lun Fu, Liming Zhang, Zuojun Wang, Zhaoyun Li |
| Abstract |
A bunch of microRNAs (miRNAs) have been demonstrated to be aberrantly expressed in cancer tumor tissue and serum. The miRNA signatures identified from the serum samples could serve as potential noninvasive diagnostic markers for breast cancer. The role of the miRNAs in cancerigenesis is unclear. In this study, we generated the expression profiles of miRNAs from the paired breast cancer tumors, normal, tissue, and serum samples from eight patients using small RNA-sequencing. Serum samples from eight healthy individuals were used as normal controls. We identified total 174 significantly differentially expressed miRNAs between tumors and the normal tissues, and 109 miRNAs between serum from patients and serum from healthy individuals. There are only 10 common miRNAs. This suggests that only a small portion of tumor miRNAs are released into serum selectively. Interestingly, the expression change pattern of 28 miRNAs is opposite between breast cancer tumors and serum. Functional analysis shows that the differentially expressed miRNAs and their target genes form a complex interaction network affecting many biological processes and involving in many types of cancer such as prostate cancer, basal cell carcinoma, acute myeloid leukemia, and more. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Belgium | 1 | <1% |
| Egypt | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 124 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 21% |
| Student > Bachelor | 20 | 16% |
| Student > Ph. D. Student | 18 | 14% |
| Student > Master | 16 | 13% |
| Student > Doctoral Student | 10 | 8% |
| Other | 17 | 13% |
| Unknown | 20 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 28% |
| Agricultural and Biological Sciences | 24 | 19% |
| Medicine and Dentistry | 20 | 16% |
| Engineering | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 16 | 13% |
| Unknown | 24 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2014.
All research outputs
#14,196,440
of 22,756,196 outputs
Outputs from Frontiers in Genetics
#3,912
of 11,758 outputs
Outputs of similar age
#119,211
of 226,570 outputs
Outputs of similar age from Frontiers in Genetics
#71
of 117 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,758 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,570 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.