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Transposable elements in cancer as a by-product of stress-induced evolvability

Overview of attention for article published in Frontiers in Genetics, May 2014
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Title
Transposable elements in cancer as a by-product of stress-induced evolvability
Published in
Frontiers in Genetics, May 2014
DOI 10.3389/fgene.2014.00156
Pubmed ID
Authors

Tobias Mourier, Lars P. Nielsen, Anders J. Hansen, Eske Willerslev

Abstract

Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock's famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted toward certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms' abilities to genetically adapt to environmental stress.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Germany 1 1%
Canada 1 1%
Belgium 1 1%
United States 1 1%
Unknown 66 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 27%
Researcher 11 15%
Student > Bachelor 7 10%
Professor > Associate Professor 7 10%
Student > Master 6 8%
Other 8 11%
Unknown 13 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 48%
Biochemistry, Genetics and Molecular Biology 15 21%
Immunology and Microbiology 2 3%
Medicine and Dentistry 2 3%
Mathematics 1 1%
Other 4 6%
Unknown 13 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2014.
All research outputs
#18,372,841
of 22,756,196 outputs
Outputs from Frontiers in Genetics
#7,008
of 11,758 outputs
Outputs of similar age
#163,146
of 226,629 outputs
Outputs of similar age from Frontiers in Genetics
#98
of 119 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,758 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,629 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.