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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic-based therapies for Friedreich ataxia
|
|---|---|
| Published in |
Frontiers in Genetics, June 2014
|
| DOI | 10.3389/fgene.2014.00165 |
| Pubmed ID | |
| Authors |
Chiranjeevi Sandi, Madhavi Sandi, Sara Anjomani Virmouni, Sahar Al-Mahdawi, Mark A. Pook |
| Abstract |
Friedreich ataxia (FRDA) is a lethal autosomal recessive neurodegenerative disorder caused primarily by a homozygous GAA repeat expansion mutation within the first intron of the FXN gene, leading to inhibition of FXN transcription and thus reduced frataxin protein expression. Recent studies have shown that epigenetic marks, comprising chemical modifications of DNA and histones, are associated with FXN gene silencing. Such epigenetic marks can be reversed, making them suitable targets for epigenetic-based therapy. Furthermore, since FRDA is caused by insufficient, but functional, frataxin protein, epigenetic-based transcriptional re-activation of the FXN gene is an attractive therapeutic option. In this review we summarize our current understanding of the epigenetic basis of FXN gene silencing and we discuss current epigenetic-based FRDA therapeutic strategies. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| Australia | 1 | 25% |
| France | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 122 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 17% |
| Student > Ph. D. Student | 17 | 14% |
| Researcher | 15 | 12% |
| Student > Master | 12 | 10% |
| Student > Postgraduate | 6 | 5% |
| Other | 20 | 16% |
| Unknown | 34 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 26% |
| Agricultural and Biological Sciences | 22 | 18% |
| Medicine and Dentistry | 16 | 13% |
| Chemistry | 7 | 6% |
| Neuroscience | 6 | 5% |
| Other | 8 | 6% |
| Unknown | 33 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2014.
All research outputs
#12,899,679
of 22,756,196 outputs
Outputs from Frontiers in Genetics
#2,720
of 11,758 outputs
Outputs of similar age
#105,500
of 227,901 outputs
Outputs of similar age from Frontiers in Genetics
#57
of 123 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,758 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.