Title |
The Missing lnc(RNA) between the pancreatic β-cell and diabetes
|
---|---|
Published in |
Frontiers in Genetics, July 2014
|
DOI | 10.3389/fgene.2014.00200 |
Pubmed ID | |
Authors |
Vasumathi Kameswaran, Klaus H Kaestner |
Abstract |
Diabetes mellitus represents a group of complex metabolic diseases that result in impaired glucose homeostasis, which includes destruction of β-cells or the failure of these insulin-secreting cells to compensate for increased metabolic demand. Despite a strong interest in characterizing the transcriptome of the different human islet cell types to understand the molecular basis of diabetes, very little attention has been paid to the role of long non-coding RNAs (lncRNAs) and their contribution to this disease. Here we summarize the growing evidence for the potential role of these lncRNAs in β-cell function and dysregulation in diabetes, with a focus on imprinted genomic loci. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 3 | 43% |
United Kingdom | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
France | 1 | <1% |
Unknown | 99 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 19% |
Student > Bachelor | 18 | 18% |
Researcher | 15 | 15% |
Student > Master | 13 | 13% |
Other | 6 | 6% |
Other | 18 | 18% |
Unknown | 12 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 35 | 35% |
Agricultural and Biological Sciences | 32 | 32% |
Medicine and Dentistry | 11 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Nursing and Health Professions | 2 | 2% |
Other | 4 | 4% |
Unknown | 15 | 15% |