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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Regulation of IGF -1 signaling by microRNAs
|
|---|---|
| Published in |
Frontiers in Genetics, January 2015
|
| DOI | 10.3389/fgene.2014.00472 |
| Pubmed ID | |
| Authors |
Hwa Jin Jung, Yousin Suh |
| Abstract |
The insulin-like growth factor 1 (IGF-1) signaling pathway regulates critical biological processes including development, homeostasis, and aging. Dysregulation of this pathway has been implicated in a myriad of diseases such as cancers, neurodegenerative diseases, and metabolic disorders, making the IGF-1 signaling pathway a prime target to develop therapeutic and intervention strategies. Recently, small non-coding RNA molecules in ∼22 nucleotide length, microRNAs (miRNAs), have emerged as a new regulator of biological processes in virtually all organ systems and increasing studies are linking altered miRNA function to disease mechanisms. A miRNA binds to 3'UTRs of multiple target genes and coordinately downregulates their expression, thereby exerting a profound influence on gene regulatory networks. Here we review the components of the IGF-1 signaling pathway that are known targets of miRNA regulation, and highlight recent studies that suggest therapeutic potential of these miRNAs against various diseases. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Switzerland | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 244 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 22% |
| Student > Bachelor | 34 | 14% |
| Student > Master | 24 | 10% |
| Researcher | 20 | 8% |
| Student > Doctoral Student | 17 | 7% |
| Other | 37 | 15% |
| Unknown | 60 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 22% |
| Biochemistry, Genetics and Molecular Biology | 50 | 20% |
| Medicine and Dentistry | 35 | 14% |
| Neuroscience | 9 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 25 | 10% |
| Unknown | 69 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2016.
All research outputs
#14,178,047
of 24,226,848 outputs
Outputs from Frontiers in Genetics
#3,170
of 13,008 outputs
Outputs of similar age
#178,289
of 361,684 outputs
Outputs of similar age from Frontiers in Genetics
#63
of 128 outputs
Altmetric has tracked 24,226,848 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,008 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,684 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 128 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.