Title |
Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease
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Published in |
Frontiers in Genetics, May 2015
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DOI | 10.3389/fgene.2015.00168 |
Pubmed ID | |
Authors |
Mustafa Işın, Ege Uysaler, Emre Özgür, Hikmet Köseoğlu, Öner Şanlı, Ömer B. Yücel, Uğur Gezer, Nejat Dalay |
Abstract |
Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa. |
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Geographical breakdown
Country | Count | As % |
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Germany | 1 | 11% |
Switzerland | 1 | 11% |
Unknown | 7 | 78% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 89% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 85 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 20% |
Researcher | 12 | 14% |
Student > Master | 10 | 12% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 4 | 5% |
Other | 14 | 16% |
Unknown | 21 | 25% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 20 | 24% |
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Medicine and Dentistry | 14 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Immunology and Microbiology | 2 | 2% |
Other | 6 | 7% |
Unknown | 24 | 28% |