Title |
Genetic variants in microRNA genes: impact on microRNA expression, function, and disease
|
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Published in |
Frontiers in Genetics, May 2015
|
DOI | 10.3389/fgene.2015.00186 |
Pubmed ID | |
Authors |
Sophia Cammaerts, Mojca Strazisar, Peter De Rijk, Jurgen Del Favero |
Abstract |
MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene, their coding sequences are subject to genetic variation. Variants in miRNA genes can have profound effects on miRNA functionality at all levels, including miRNA transcription, maturation, and target specificity, and as such they can also contribute to disease. The impact of variants in miRNA genes is the focus of the present review. To put these effects into context, we first discuss the requirements of miRNA transcripts for maturation. In the last part an overview of available databases and tools and experimental approaches to investigate miRNA variants related to human disease is presented. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 166 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 23% |
Researcher | 27 | 16% |
Student > Master | 14 | 8% |
Student > Doctoral Student | 12 | 7% |
Student > Bachelor | 10 | 6% |
Other | 27 | 16% |
Unknown | 40 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 47 | 28% |
Agricultural and Biological Sciences | 37 | 22% |
Medicine and Dentistry | 9 | 5% |
Computer Science | 6 | 4% |
Neuroscience | 5 | 3% |
Other | 16 | 10% |
Unknown | 48 | 29% |