Title |
The Impact of KIR Polymorphism on the Risk of Developing Cancer: Not as Strong as Imagined?
|
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Published in |
Frontiers in Genetics, June 2016
|
DOI | 10.3389/fgene.2016.00121 |
Pubmed ID | |
Authors |
Danillo G. Augusto |
Abstract |
The polymorphism of killer cell immunoglobulin-like receptors (KIR) has been associated with several diseases, including infection, autoimmunity and cancer. KIR molecules are a family of receptors expressed on the surface of natural killer cells (NK), frontline defense of innate immunity against microorganisms and neoplastic cells. Some studies have shown conflicting results concerning the role that KIR polymorphism plays in tumor susceptibility, particularly in leukemia and lymphoma. Interestingly, the presence of HLA ligands is sometimes strongly associated with several types of cancer and apparently is not related with their interaction with KIR. This manuscript briefly reviews the uncommon polymorphism of KIR and critically summarizes the recent findings with regards of the importance of KIR variation for cancer susceptibility. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 23% |
Student > Master | 11 | 21% |
Student > Ph. D. Student | 9 | 17% |
Student > Doctoral Student | 5 | 10% |
Student > Bachelor | 2 | 4% |
Other | 2 | 4% |
Unknown | 11 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 27% |
Immunology and Microbiology | 11 | 21% |
Agricultural and Biological Sciences | 9 | 17% |
Medicine and Dentistry | 5 | 10% |
Nursing and Health Professions | 2 | 4% |
Other | 1 | 2% |
Unknown | 10 | 19% |