Title |
ApoptomiRs of Breast Cancer: Basics to Clinics
|
---|---|
Published in |
Frontiers in Genetics, September 2016
|
DOI | 10.3389/fgene.2016.00175 |
Pubmed ID | |
Authors |
Shivani Sharma, Praveen K. Patnaik, Stella Aronov, Ritu Kulshreshtha |
Abstract |
Apoptosis, a form of programmed cell death, is a highly regulated process, the deregulation of which has been associated with the tumor initiation, progression, and metastasis in various cancers including breast cancer. Induction of apoptosis is a popular target of various therapies currently being tested or used for breast cancer treatment. Thus, identifying apoptotic mediators and regulators is imperative for molecular biologists and clinicians for benefit of patients. The regulation of apoptosis is complex and involves a tight equilibrium between the pro- and anti-apoptotic factors. Recent studies have highlighted the role of miRNAs in the control of apoptosis and their interplay with p53, the master guardian of apoptosis. Here, we summarize and integrate the data on the role of miRNAs in apoptosis in breast cancer and the clinical advantage it may offer for the prognosis or treatment of breast cancer patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 3% |
Unknown | 37 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 26% |
Student > Master | 5 | 13% |
Researcher | 4 | 11% |
Student > Bachelor | 3 | 8% |
Librarian | 3 | 8% |
Other | 5 | 13% |
Unknown | 8 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 24% |
Medicine and Dentistry | 6 | 16% |
Agricultural and Biological Sciences | 4 | 11% |
Chemistry | 2 | 5% |
Nursing and Health Professions | 1 | 3% |
Other | 5 | 13% |
Unknown | 11 | 29% |