Title |
Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases
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Published in |
Frontiers in Genetics, January 2017
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DOI | 10.3389/fgene.2017.00007 |
Pubmed ID | |
Authors |
Andreas D. Flouris, Yulii V. Shidlovskii, Alexander V. Shaposhnikov, Levon Yepiskoposyan, Liliya Nadolnik, Lidia Karabon, Anna Kowalska, Andres E. Carrillo, George S. Metsios, Paraskevi Sakellariou |
Abstract |
Cardio-metabolic diseases (CMDs) comprise a cluster of risk factors that contribute to chronic pathological conditions with adverse consequences for cardiovascular function and metabolic processes. A wide range of CMD prevalence rates among different ethnic groups has been documented. In view of accumulated evidence, there is a trend toward increasing CMD prevalence rates in Eastern Europe and Western Asia. Numerous studies have revealed an association between uncoupling protein 1 (UCP1) gene variants and CMDs. UCP1 activity is essential for brown adipose tissue (BAT)-mediated thermogenesis. Experimental animal studies and epidemiological studies in humans highlight the significance of BAT-mediated thermogenesis in protecting against obesity and maintaining a lean phenotype. We hypothesize that the genetic variation in UCP1 gene expression observed among different ethnic groups could contribute to the ethnic-specific predisposition to CMD development. Constructing such prevalence maps of UCP1 gene variants could contribute significantly into identifying high-risk ethnic groups predisposed to the development of CMDs, and further shaping public health policies by the improvement of existing preventive and management strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Greece | 2 | 40% |
Mexico | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 40% |
Scientists | 2 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 20% |
Student > Bachelor | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Student > Master | 2 | 7% |
Other | 5 | 17% |
Unknown | 8 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 20% |
Agricultural and Biological Sciences | 3 | 10% |
Nursing and Health Professions | 3 | 10% |
Environmental Science | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Other | 5 | 17% |
Unknown | 9 | 30% |