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Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases

Overview of attention for article published in Frontiers in Genetics, January 2017
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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Title
Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases
Published in
Frontiers in Genetics, January 2017
DOI 10.3389/fgene.2017.00007
Pubmed ID
Authors

Andreas D. Flouris, Yulii V. Shidlovskii, Alexander V. Shaposhnikov, Levon Yepiskoposyan, Liliya Nadolnik, Lidia Karabon, Anna Kowalska, Andres E. Carrillo, George S. Metsios, Paraskevi Sakellariou

Abstract

Cardio-metabolic diseases (CMDs) comprise a cluster of risk factors that contribute to chronic pathological conditions with adverse consequences for cardiovascular function and metabolic processes. A wide range of CMD prevalence rates among different ethnic groups has been documented. In view of accumulated evidence, there is a trend toward increasing CMD prevalence rates in Eastern Europe and Western Asia. Numerous studies have revealed an association between uncoupling protein 1 (UCP1) gene variants and CMDs. UCP1 activity is essential for brown adipose tissue (BAT)-mediated thermogenesis. Experimental animal studies and epidemiological studies in humans highlight the significance of BAT-mediated thermogenesis in protecting against obesity and maintaining a lean phenotype. We hypothesize that the genetic variation in UCP1 gene expression observed among different ethnic groups could contribute to the ethnic-specific predisposition to CMD development. Constructing such prevalence maps of UCP1 gene variants could contribute significantly into identifying high-risk ethnic groups predisposed to the development of CMDs, and further shaping public health policies by the improvement of existing preventive and management strategies.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Student > Bachelor 4 13%
Student > Ph. D. Student 3 10%
Student > Doctoral Student 2 7%
Student > Master 2 7%
Other 5 17%
Unknown 8 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 20%
Agricultural and Biological Sciences 3 10%
Nursing and Health Professions 3 10%
Environmental Science 2 7%
Immunology and Microbiology 2 7%
Other 5 17%
Unknown 9 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2017.
All research outputs
#7,266,533
of 22,947,506 outputs
Outputs from Frontiers in Genetics
#2,314
of 11,974 outputs
Outputs of similar age
#138,589
of 420,054 outputs
Outputs of similar age from Frontiers in Genetics
#13
of 42 outputs
Altmetric has tracked 22,947,506 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 11,974 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.