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New Insights into 5hmC DNA Modification: Generation, Distribution and Function

Overview of attention for article published in Frontiers in Genetics, July 2017
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

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325 Mendeley
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Title
New Insights into 5hmC DNA Modification: Generation, Distribution and Function
Published in
Frontiers in Genetics, July 2017
DOI 10.3389/fgene.2017.00100
Pubmed ID
Authors

Dong-Qiao Shi, Iftikhar Ali, Jun Tang, Wei-Cai Yang

Abstract

Dynamic DNA modifications, such as methylation/demethylation on cytosine, are major epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In addition to the common methylation on the 5th position of the pyrimidine ring of cytosine (5mC), other types of modifications at the same position, such as 5-hydroxymethyl (5hmC), 5-formyl (5fC), and 5-carboxyl (5caC), are also important. Recently, 5hmC, a product of 5mC demethylation by the Ten-Eleven Translocation family proteins, was shown to regulate many cellular and developmental processes, including the pluripotency of embryonic stem cells, neuron development, and tumorigenesis in mammals. Here, we review recent advances on the generation, distribution, and function of 5hmC modification in mammals and discuss its potential roles in plants.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 325 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 325 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 77 24%
Researcher 44 14%
Student > Master 39 12%
Student > Bachelor 37 11%
Student > Doctoral Student 21 6%
Other 25 8%
Unknown 82 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 120 37%
Agricultural and Biological Sciences 52 16%
Medicine and Dentistry 19 6%
Chemistry 11 3%
Neuroscience 9 3%
Other 26 8%
Unknown 88 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2019.
All research outputs
#14,092,832
of 24,911,633 outputs
Outputs from Frontiers in Genetics
#2,890
of 13,419 outputs
Outputs of similar age
#151,880
of 320,198 outputs
Outputs of similar age from Frontiers in Genetics
#21
of 40 outputs
Altmetric has tracked 24,911,633 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,419 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,198 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.