Title |
New Insights into 5hmC DNA Modification: Generation, Distribution and Function
|
---|---|
Published in |
Frontiers in Genetics, July 2017
|
DOI | 10.3389/fgene.2017.00100 |
Pubmed ID | |
Authors |
Dong-Qiao Shi, Iftikhar Ali, Jun Tang, Wei-Cai Yang |
Abstract |
Dynamic DNA modifications, such as methylation/demethylation on cytosine, are major epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In addition to the common methylation on the 5th position of the pyrimidine ring of cytosine (5mC), other types of modifications at the same position, such as 5-hydroxymethyl (5hmC), 5-formyl (5fC), and 5-carboxyl (5caC), are also important. Recently, 5hmC, a product of 5mC demethylation by the Ten-Eleven Translocation family proteins, was shown to regulate many cellular and developmental processes, including the pluripotency of embryonic stem cells, neuron development, and tumorigenesis in mammals. Here, we review recent advances on the generation, distribution, and function of 5hmC modification in mammals and discuss its potential roles in plants. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 2 | 40% |
United States | 2 | 40% |
United Kingdom | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 325 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 77 | 24% |
Researcher | 44 | 14% |
Student > Master | 39 | 12% |
Student > Bachelor | 37 | 11% |
Student > Doctoral Student | 21 | 6% |
Other | 25 | 8% |
Unknown | 82 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 120 | 37% |
Agricultural and Biological Sciences | 52 | 16% |
Medicine and Dentistry | 19 | 6% |
Chemistry | 11 | 3% |
Neuroscience | 9 | 3% |
Other | 26 | 8% |
Unknown | 88 | 27% |