Title |
Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson’s Disease
|
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Published in |
Frontiers in Genetics, November 2017
|
DOI | 10.3389/fgene.2017.00177 |
Pubmed ID | |
Authors |
Martin P. Helley, Jennifer Pinnell, Carolina Sportelli, Kim Tieu |
Abstract |
Parkinson's disease (PD) is a devastating neurological movement disorder. Since its first discovery 200 years ago, genetic and environmental factors have been identified to play a role in PD development and progression. Although genetic studies have been the predominant driving force in PD research over the last few decades, currently only a small fraction of PD cases can be directly linked to monogenic mutations. The remaining cases have been attributed to other risk associated genes, environmental exposures and gene-environment interactions, making PD a multifactorial disorder with a complex etiology. However, enormous efforts from global research have yielded significant insights into pathogenic mechanisms and potential therapeutic targets for PD. This review will highlight mitochondrial dysfunction as a common pathway involved in both genetic mutations and environmental toxicants linked to PD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 44% |
Switzerland | 2 | 22% |
Korea, Democratic People's Republic of | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 56% |
Scientists | 4 | 44% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 95 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 18 | 19% |
Student > Master | 17 | 18% |
Student > Ph. D. Student | 14 | 15% |
Researcher | 8 | 8% |
Student > Doctoral Student | 5 | 5% |
Other | 11 | 12% |
Unknown | 22 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 24 | 25% |
Neuroscience | 13 | 14% |
Medicine and Dentistry | 8 | 8% |
Agricultural and Biological Sciences | 7 | 7% |
Environmental Science | 3 | 3% |
Other | 15 | 16% |
Unknown | 25 | 26% |