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Mendeley readers
Attention Score in Context
| Title |
Insertion/Deletion Within the KDM6A Gene Is Significantly Associated With Litter Size in Goat
|
|---|---|
| Published in |
Frontiers in Genetics, March 2018
|
| DOI | 10.3389/fgene.2018.00091 |
| Pubmed ID | |
| Authors |
Yang Cui, Hailong Yan, Ke Wang, Han Xu, Xuelian Zhang, Haijing Zhu, Jinwang Liu, Lei Qu, Xianyong Lan, Chuanying Pan |
| Abstract |
A previous whole-genome association analysis identifiedlysine demethylase 6A(KDM6A), which encodes a type of histone demethylase, as a candidate gene associated to goat fecundity.KDM6Agene knockout mouse disrupts gametophyte development, suggesting that it has a critical role in reproduction. In this study, goatKDM6AmRNA expression profiles were determined, insertion/deletion (indel) variants in the gene identified, indel variants effect onKDM6Agene expression assessed, and their association with first-born litter size analyzed in 2326 healthy female Shaanbei white cashmere goats.KDM6AmRNA was expressed in all tissues tested (heart, liver, spleen, lung, kidney, muscle, brain, skin and testis); the expression levels in testes at different developmental stages [1-week-old (wk), 2, 3 wk, 1-month-old (mo), 1.5 and 2 mo] indicated a potential association with the mitosis-to-meiosis transition, implying thatKDM6Amay have an essential role in goat fertility. Meanwhile, two novel intronic indels of 16 bp and 5 bp were identified. Statistical analysis revealed that only the 16 bp indel was associated with first-born litter size (P< 0.01), and the average first-born litter size of individuals with an insertion/insertion genotype higher than that of those with the deletion/deletion genotype (P< 0.05). There was also a significant difference in genotype distributions of the 16 bp indel between mothers of single-lamb and multi-lamb litters in the studied goat population (P= 0.001). Consistently, the 16 bp indel also had a significant effect onKDM6Agene expression. Additionally, there was no significant linkage disequilibrium (LD) between these two indel loci, consistent with the association analysis results. Together, these findings suggest that the 16 bp indel inKDM6Amay be useful for marker-assisted selection (MAS) of goats. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 20% |
| Australia | 2 | 20% |
| Nigeria | 1 | 10% |
| Japan | 1 | 10% |
| United States | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
| Scientists | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 27% |
| Student > Ph. D. Student | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Lecturer > Senior Lecturer | 1 | 5% |
| Lecturer | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 8 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 32% |
| Biochemistry, Genetics and Molecular Biology | 4 | 18% |
| Veterinary Science and Veterinary Medicine | 2 | 9% |
| Unknown | 9 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2019.
All research outputs
#6,976,980
of 23,028,364 outputs
Outputs from Frontiers in Genetics
#2,164
of 12,076 outputs
Outputs of similar age
#122,783
of 332,278 outputs
Outputs of similar age from Frontiers in Genetics
#45
of 140 outputs
Altmetric has tracked 23,028,364 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 12,076 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,278 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.