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Mendeley readers
Attention Score in Context
| Title |
Associations Between XPD Lys751Gln Polymorphism and Leukemia: A Meta-Analysis
|
|---|---|
| Published in |
Frontiers in Genetics, June 2018
|
| DOI | 10.3389/fgene.2018.00218 |
| Pubmed ID | |
| Authors |
Min Wen, Bo Zhou, Xin Lin, Yunhua Chen, Jialei Song, Yanmei Li, Eldad Zacksenhaus, Yaacov Ben-David, Xiaojiang Hao |
| Abstract |
Objectives: The aim of the present study was to define the potential relationship between xeroderma pigmentosum group D (XPD) Lys751Gln polymorphisms and the risk of leukemia. Methods: A comprehensive search of Pubmed, Web of Science, EBSCO, the Cochrane Library and China National Knowledge Infrastructure was conducted to identify original articles published before March 2017 concerning the association between XPD Lys751Gln polymorphisms and leukemia risk. A literature quality assessment was performed using the Newcastle-Ottawa Scale. Heterogeneity across studies was assessed using I2 statistics. Random- or fixed-effects models were used to calculate pooled odds ratios (ORs) in the presence or absence of heterogeneity, respectively. Sensitivity analysis was used to assess the influence of individual studies on the pooled estimate. Publication bias was investigated using funnel plots and Egger's regression test. All data analyses were performed using Stata 14.0 and Revman 5.3. Results: Fourteen studies with a total of 7525 participants (2,757 patients; 4,768 controls) were included in this meta-analysis. We found that XPD Lys751Gln polymorphisms significantly increased the risk of developing leukemia in both dominant OR = 1.21, 95%CI [1.10-1.35], P ≤ 0.001) and heterozygote (OR = 1.22, 95%CI [1.09-1.36], P ≤ 0.001) model. An allele model showed a borderline significant increase in leukemia risk (OR = 1.13, 95%CI [1.00-1.27], P = 0.05). A subgroup analysis revealed a consistent association between XPD Lys751Gln polymorphisms and leukemia risk for some genetic models in Caucasian populations, adult or chronic groups, and in almost all models of childhood or acute groups. Conclusion: Our results indicate that XPD Lys751Gln polymorphism increases the risk of leukemia, especially in childhood and acute cases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 27% |
| Other | 2 | 18% |
| Lecturer | 1 | 9% |
| Lecturer > Senior Lecturer | 1 | 9% |
| Student > Master | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 2 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 27% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 18% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Economics, Econometrics and Finance | 1 | 9% |
| Agricultural and Biological Sciences | 1 | 9% |
| Other | 2 | 18% |
| Unknown | 1 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2018.
All research outputs
#20,522,137
of 23,090,520 outputs
Outputs from Frontiers in Genetics
#8,771
of 12,141 outputs
Outputs of similar age
#288,112
of 328,563 outputs
Outputs of similar age from Frontiers in Genetics
#115
of 120 outputs
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So far Altmetric has tracked 12,141 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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