Title |
Role of Signaling Molecules in Mitochondrial Stress Response
|
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Published in |
Frontiers in Genetics, July 2018
|
DOI | 10.3389/fgene.2018.00225 |
Pubmed ID | |
Authors |
Shauna Hill, Kavithalakshmi Sataranatarajan, Holly Van Remmen |
Abstract |
Mitochondria are established essential regulators of cellular function and metabolism. Mitochondria regulate redox homeostasis, maintain energy (ATP) production through oxidative phosphorylation, buffer calcium levels, and control cell death through apoptosis. In addition to these critical cell functions, recent evidence supports a signaling role for mitochondria. For example, studies over the past few years have established that peptides released from the mitochondria mediate stress responses such as the mitochondrial unfolded protein response (UPRMT) through signaling to the nucleus. Mitochondrial damage or danger associated molecular patterns (DAMPs) provide a link between mitochondria, inflammation and inflammatory disease processes. Additionally, a new class of peptides generated by the mitochondria affords protection against age-related diseases in mammals. In this short review, we highlight the role of mitochondrial signaling and regulation of cellular activities through the mitochondrial UPRMT that signals to the nucleus to affect homeostatic responses, DAMPs, and mitochondrial derived peptides. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 14 | 19% |
United Kingdom | 10 | 14% |
Spain | 5 | 7% |
Australia | 4 | 5% |
Switzerland | 2 | 3% |
Canada | 1 | 1% |
Germany | 1 | 1% |
Austria | 1 | 1% |
Finland | 1 | 1% |
Other | 3 | 4% |
Unknown | 31 | 42% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 59 | 81% |
Scientists | 12 | 16% |
Practitioners (doctors, other healthcare professionals) | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 80 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 24% |
Researcher | 13 | 16% |
Student > Bachelor | 10 | 13% |
Student > Master | 6 | 8% |
Student > Doctoral Student | 3 | 4% |
Other | 8 | 10% |
Unknown | 21 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 27 | 34% |
Agricultural and Biological Sciences | 16 | 20% |
Medicine and Dentistry | 5 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 6 | 8% |
Unknown | 22 | 28% |