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Processing of DNA Ends in the Maintenance of Genome Stability

Overview of attention for article published in Frontiers in Genetics, September 2018
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Title
Processing of DNA Ends in the Maintenance of Genome Stability
Published in
Frontiers in Genetics, September 2018
DOI 10.3389/fgene.2018.00390
Pubmed ID
Authors

Diego Bonetti, Chiara Vittoria Colombo, Michela Clerici, Maria Pia Longhese

Abstract

DNA double-strand breaks (DSBs) are particularly hazardous lesions as their inappropriate repair can result in chromosome rearrangements, an important driving force of tumorigenesis. DSBs can be repaired by end joining mechanisms or by homologous recombination (HR). HR requires the action of several nucleases that preferentially remove the 5'-terminated strands at both DSB ends in a process called DNA end resection. The same nucleases are also involved in the processing of replication fork structures. Much of our understanding of these pathways has come from studies in the model organism Saccharomyces cerevisiae. Here, we review the current knowledge of the mechanism of resection at DNA DSBs and replication forks.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 25%
Researcher 8 15%
Student > Master 8 15%
Student > Doctoral Student 4 8%
Student > Bachelor 3 6%
Other 7 13%
Unknown 10 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 51%
Agricultural and Biological Sciences 9 17%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Environmental Science 1 2%
Immunology and Microbiology 1 2%
Other 1 2%
Unknown 13 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2019.
All research outputs
#14,425,183
of 23,103,436 outputs
Outputs from Frontiers in Genetics
#4,011
of 12,152 outputs
Outputs of similar age
#189,453
of 337,668 outputs
Outputs of similar age from Frontiers in Genetics
#109
of 225 outputs
Altmetric has tracked 23,103,436 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,152 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,668 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 225 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.