Title |
Cumulative Autoimmunity: T Cell Clones Recognizing Several Self-Epitopes Exhibit Enhanced Pathogenicity
|
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Published in |
Frontiers in immunology, January 2011
|
DOI | 10.3389/fimmu.2011.00047 |
Pubmed ID | |
Authors |
Roland S. Liblau, Hartmut Wekerle, Roland M. Tisch |
Abstract |
T cell receptor (TCR) recognition is intrinsically polyspecific. In the field of autoimmunity, recognition of both self- and microbial peptides by a single TCR has led to the concept of molecular mimicry. However, findings made by our group and others clearly demonstrate that a given TCR can also recognize multiple distinct self-peptides. Based on experimental data we argue that recognition of several self-peptides increases the pathogenicity of an autoreactive T cell; a property we refer to as "cumulative autoimmunity." The mechanisms of such increased pathogenicity, and the implications of cumulative autoimmunity regarding the pathophysiology of T cell-mediated autoimmune diseases will be discussed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 24% |
Student > Master | 4 | 19% |
Other | 3 | 14% |
Professor > Associate Professor | 2 | 10% |
Student > Ph. D. Student | 1 | 5% |
Other | 3 | 14% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 33% |
Immunology and Microbiology | 4 | 19% |
Medicine and Dentistry | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Neuroscience | 2 | 10% |
Other | 0 | 0% |
Unknown | 3 | 14% |