Title |
The Commensal Microbiota Drives Immune Homeostasis
|
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Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00033 |
Pubmed ID | |
Authors |
Marie-Claire Arrieta, Barton Brett Finlay |
Abstract |
For millions of years, microbes have coexisted with eukaryotic cells at the mucosal surfaces of vertebrates in a complex, yet usually harmonious symbiosis. An ever-expanding number of reports describe how eliminating or shifting the intestinal microbiota has profound effects on the development and functionality of the mucosal and systemic immune systems. Here, we examine some of the mechanisms by which bacterial signals affect immune homeostasis. Focusing on the strategies that microbes use to keep our immune system healthy, as opposed to trying to correct the immune imbalances caused by dysbiosis, may prove to be a more astute and efficient way of treating immune-mediated disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
United States | 1 | <1% |
Portugal | 1 | <1% |
France | 1 | <1% |
Unknown | 166 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 37 | 22% |
Student > Ph. D. Student | 32 | 19% |
Student > Master | 27 | 16% |
Student > Bachelor | 20 | 12% |
Student > Doctoral Student | 13 | 8% |
Other | 21 | 12% |
Unknown | 21 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 65 | 38% |
Immunology and Microbiology | 24 | 14% |
Biochemistry, Genetics and Molecular Biology | 20 | 12% |
Medicine and Dentistry | 19 | 11% |
Environmental Science | 4 | 2% |
Other | 16 | 9% |
Unknown | 23 | 13% |