Title |
Autophagy and Mechanisms of Effective Immunity
|
---|---|
Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00060 |
Pubmed ID | |
Authors |
Justine D. Mintern, Jose A. Villadangos |
Abstract |
Macroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, autophagy is a major pathway of degradation. It enables elimination of microbes that have invaded intracellular compartments. In addition, it promotes degradation of damaged cellular content, thereby acting to limit inflammatory signals. Second, autophagy is a major trafficking pathway, shuttling content between the cytosol and the lysosomal compartment. Given these two key roles, autophagy can have significant and sometimes unexpected consequences on mechanisms that initiate robust immunity. Here, we will discuss the impact of autophagy on pathways of innate and adaptive immune responses including microbe elimination, inflammatory cytokine production, antigen processing and T and B lymphocyte immunity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 2% |
Netherlands | 1 | 2% |
Australia | 1 | 2% |
United Kingdom | 1 | 2% |
Venezuela, Bolivarian Republic of | 1 | 2% |
Unknown | 37 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 29% |
Student > Master | 6 | 14% |
Researcher | 5 | 12% |
Student > Bachelor | 4 | 10% |
Other | 3 | 7% |
Other | 6 | 14% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 48% |
Medicine and Dentistry | 5 | 12% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Immunology and Microbiology | 3 | 7% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 5% |
Unknown | 7 | 17% |