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Antimicrobial Chemokines

Overview of attention for article published in Frontiers in immunology, January 2012
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Title
Antimicrobial Chemokines
Published in
Frontiers in immunology, January 2012
DOI 10.3389/fimmu.2012.00276
Pubmed ID
Authors

Sunny C. Yung, Philip M. Murphy

Abstract

Chemokines are best known for their classic leukocyte chemotactic activity, which is critical for directing the immune response to sites of infection and injury. However, recent studies have suggested that at least some chemokines may also interfere with infectious agents directly. Antimicrobial chemokines tend to contain amphipathic alpha helical secondary structure, and broad-spectrum activity against both Gram-positive and Gram negative bacteria, as well as fungi. Conversely, several bacteria have been identified that possess mechanisms for specifically blocking the antimicrobial activities of chemokines. Although the precise mechanisms by which chemokines and microbes disarm one another in vitro remain unknown, there is now emerging evidence in vivo that such interactions may be biologically significant. More research will be needed to determine whether chemokines with direct antimicrobial activity may be translated into a novel class of antibiotics.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Brazil 1 2%
Unknown 57 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 27%
Researcher 11 19%
Student > Master 8 14%
Other 6 10%
Student > Doctoral Student 4 7%
Other 9 15%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 34%
Immunology and Microbiology 10 17%
Biochemistry, Genetics and Molecular Biology 9 15%
Medicine and Dentistry 6 10%
Unspecified 1 2%
Other 2 3%
Unknown 11 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2012.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Frontiers in immunology
#27,422
of 31,520 outputs
Outputs of similar age
#228,483
of 250,099 outputs
Outputs of similar age from Frontiers in immunology
#161
of 275 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,099 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 275 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.