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The integration of signaling and the spatial organization of the T cell synapse

Overview of attention for article published in Frontiers in immunology, January 2012
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Title
The integration of signaling and the spatial organization of the T cell synapse
Published in
Frontiers in immunology, January 2012
DOI 10.3389/fimmu.2012.00352
Pubmed ID
Authors

Jérémie Rossy, David J. Williamson, Carola Benzing, Katharina Gaus

Abstract

Engagement of the T cell antigen receptor (TCR) triggers signaling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor molecules, dimers, oligomers and higher order structures. Here we discuss recent findings and new concepts that may regulate TCR organization in naïve and memory T cells. A key question that has emerged is how antigen-TCR interactions encode spatial information to direct T cell activation and differentiation. Single molecule super-resolution microscopy may become an important tool in decoding receptor organization at the molecular level.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Germany 2 1%
Australia 1 <1%
Japan 1 <1%
United Kingdom 1 <1%
Unknown 136 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 33%
Researcher 32 22%
Student > Master 15 10%
Student > Bachelor 12 8%
Student > Doctoral Student 6 4%
Other 21 15%
Unknown 10 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 37%
Immunology and Microbiology 24 17%
Biochemistry, Genetics and Molecular Biology 23 16%
Chemistry 9 6%
Medicine and Dentistry 8 6%
Other 17 12%
Unknown 10 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2012.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Frontiers in immunology
#27,421
of 31,520 outputs
Outputs of similar age
#228,486
of 250,100 outputs
Outputs of similar age from Frontiers in immunology
#161
of 275 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,100 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 275 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.