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Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss

Overview of attention for article published in Frontiers in immunology, January 2012
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  • High Attention Score compared to outputs of the same age and source (84th percentile)

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Title
Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss
Published in
Frontiers in immunology, January 2012
DOI 10.3389/fimmu.2012.00362
Pubmed ID
Authors

Sinuhe Hahn, Stavros Giaglis, Irene Hoesli, Paul Hasler

Abstract

The intention of this review is to provide an overview of the potential role of neutrophil extracellular traps (NETs) in mammalian reproduction. Neutrophil NETs appear to be involved in various stages of the reproductive cycle, starting with fertility and possibly ending with fetal loss. The first suggestion that NETs may play a role in pregnancy-related disorders was in preeclampsia, where vast numbers were detected in the intervillous space of affected placentae. The induction of NETosis involved an auto-inflammatory component, mediated by the increased release of placental micro-debris in preeclampsia. This report was the first indicating that NETs may be associated with a human pathology not involving infection. Subsequently, NETs have since then been implicated in bovine or equine infertility, in that semen may become entrapped in the female reproductive tract during their passage to the oocyte. In this instance interesting species-specific differences are apparent, in that equine sperm evade entrapment via expression of a DNAse-like molecule, whereas highly motile bovine sperm, once free from seminal plasma (SP) that promotes interaction with neutrophils, appear impervious to NETs entrapment. Although still in the realm of speculation it is plausible that NETs may be involved in recurrent fetal loss mediated by anti-phospholipid antibodies, or perhaps even in fetal abortion triggered by infections with microorganisms such as L. monocytogenes or B. abortus.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Unknown 130 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 16%
Researcher 13 10%
Student > Bachelor 13 10%
Student > Master 11 8%
Student > Doctoral Student 10 8%
Other 28 21%
Unknown 35 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 18%
Biochemistry, Genetics and Molecular Biology 22 17%
Medicine and Dentistry 22 17%
Immunology and Microbiology 10 8%
Veterinary Science and Veterinary Medicine 3 2%
Other 12 9%
Unknown 38 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2021.
All research outputs
#7,205,295
of 25,374,647 outputs
Outputs from Frontiers in immunology
#8,110
of 31,516 outputs
Outputs of similar age
#59,348
of 250,101 outputs
Outputs of similar age from Frontiers in immunology
#38
of 275 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 31,516 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,101 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 275 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.