Title |
A NET Outcome
|
---|---|
Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00365 |
Pubmed ID | |
Authors |
Thea Lu, Scott D. Kobayashi, Mark T. Quinn, Frank R. DeLeo |
Abstract |
Neutrophils constitute a critical part of innate immunity and are well known for their ability to phagocytose and kill invading microorganisms. The microbicidal processes employed by neutrophils are highly effective at killing most ingested bacteria and fungi. However, an alternative non-phagocytic antimicrobial mechanism of neutrophils has been proposed whereby microorganisms are eliminated by neutrophil extracellular traps (NETs). NETs are comprised of DNA, histones, and antimicrobial proteins extruded by neutrophils during NETosis, a cell death pathway reported to be distinct from apoptosis, phagocytosis-induced cell death, and necrosis. Although multiple laboratories have reported NETs using various stimuli in vitro, the molecular mechanisms involved in this process have yet to be definitively elucidated, and many questions regarding the formation and putative role or function of NETs in innate host defense remain unanswered. It is with these questions in mind that we provide some reflection and perspective on NETs and NETosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | 1% |
United States | 1 | <1% |
Poland | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 132 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 23% |
Researcher | 28 | 20% |
Student > Master | 15 | 11% |
Student > Bachelor | 12 | 9% |
Professor | 9 | 7% |
Other | 22 | 16% |
Unknown | 20 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 57 | 42% |
Biochemistry, Genetics and Molecular Biology | 16 | 12% |
Medicine and Dentistry | 15 | 11% |
Immunology and Microbiology | 13 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 5 | 4% |
Unknown | 27 | 20% |