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The emerging role of neutrophils in thrombosis—the journey of TF through NETs

Overview of attention for article published in Frontiers in immunology, January 2012
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  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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Title
The emerging role of neutrophils in thrombosis—the journey of TF through NETs
Published in
Frontiers in immunology, January 2012
DOI 10.3389/fimmu.2012.00385
Pubmed ID
Authors

Konstantinos Kambas, Ioannis Mitroulis, Konstantinos Ritis

Abstract

The production of TF by neutrophils and their contribution in thrombosis was until recently a matter of scientific debate. Experimental data suggested the de novo TF production by neutrophils under inflammatory stimuli, while others proposed that these cells acquired microparticle-derived TF. Recent experimental evidence revealed the critical role of neutrophils in thrombotic events. Neutrophil derived TF has been implicated in this process in several human and animal models. Additionally, neutrophil extracellular trap (NET) release has emerged as a major contributor in neutrophil-driven thrombogenicity in disease models including sepsis, deep venous thrombosis, and malignancy. It is suggested that NETs provide the scaffold for fibrin deposition and platelet entrapment and subsequent activation. The recently reported autophagy-dependent extracellular delivery of TF in NETs further supports the involvement of neutrophils in thrombosis. Herein, we seek to review novel data regarding the role of neutrophils in thrombosis, emphasizing the implication of TF and NETs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Netherlands 1 <1%
Sweden 1 <1%
United States 1 <1%
Poland 1 <1%
Unknown 101 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 20%
Researcher 18 17%
Student > Master 11 10%
Student > Doctoral Student 8 8%
Student > Bachelor 8 8%
Other 25 24%
Unknown 15 14%
Readers by discipline Count As %
Medicine and Dentistry 28 26%
Agricultural and Biological Sciences 22 21%
Biochemistry, Genetics and Molecular Biology 14 13%
Immunology and Microbiology 13 12%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 7 7%
Unknown 19 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2012.
All research outputs
#17,236,404
of 25,374,647 outputs
Outputs from Frontiers in immunology
#20,123
of 31,520 outputs
Outputs of similar age
#172,167
of 250,100 outputs
Outputs of similar age from Frontiers in immunology
#128
of 275 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,100 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 275 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.