Title |
The emerging role of neutrophils in thrombosis—the journey of TF through NETs
|
---|---|
Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00385 |
Pubmed ID | |
Authors |
Konstantinos Kambas, Ioannis Mitroulis, Konstantinos Ritis |
Abstract |
The production of TF by neutrophils and their contribution in thrombosis was until recently a matter of scientific debate. Experimental data suggested the de novo TF production by neutrophils under inflammatory stimuli, while others proposed that these cells acquired microparticle-derived TF. Recent experimental evidence revealed the critical role of neutrophils in thrombotic events. Neutrophil derived TF has been implicated in this process in several human and animal models. Additionally, neutrophil extracellular trap (NET) release has emerged as a major contributor in neutrophil-driven thrombogenicity in disease models including sepsis, deep venous thrombosis, and malignancy. It is suggested that NETs provide the scaffold for fibrin deposition and platelet entrapment and subsequent activation. The recently reported autophagy-dependent extracellular delivery of TF in NETs further supports the involvement of neutrophils in thrombosis. Herein, we seek to review novel data regarding the role of neutrophils in thrombosis, emphasizing the implication of TF and NETs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Sweden | 1 | <1% |
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 101 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 20% |
Researcher | 18 | 17% |
Student > Master | 11 | 10% |
Student > Doctoral Student | 8 | 8% |
Student > Bachelor | 8 | 8% |
Other | 25 | 24% |
Unknown | 15 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 26% |
Agricultural and Biological Sciences | 22 | 21% |
Biochemistry, Genetics and Molecular Biology | 14 | 13% |
Immunology and Microbiology | 13 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 7 | 7% |
Unknown | 19 | 18% |