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RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways

Overview of attention for article published in Frontiers in immunology, January 2012
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Title
RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways
Published in
Frontiers in immunology, January 2012
DOI 10.3389/fimmu.2012.00398
Pubmed ID
Authors

Ram K. C. Venigalla, Martin Turner

Abstract

Understanding the mechanisms by which signal transduction pathways mediate changes in RNA abundance requires the examination of the fate of RNA from its transcription to its degradation. Evidence suggests that RNA abundance is partly regulated by post-transcriptional mechanisms affecting RNA decay and this in turn is modulated by some of the same signaling pathways that control transcription. Furthermore, the translation of mRNA is a key regulatory step that is influenced by signal transduction. These processes are regulated, in part, by RNA-binding proteins (RBPs) which bind to sequence-specific RNA elements. The function of RBPs is controlled and co-ordinated by phosphorylation. Based on the current literature we hypothesize that RBPs may be a point of convergence for the activity of different kinases such as phosphoinositide-3-kinase and mitogen-activated protein kinase which regulate RBP localization and function.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 72 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 25%
Researcher 12 16%
Student > Bachelor 6 8%
Professor > Associate Professor 6 8%
Student > Doctoral Student 5 7%
Other 12 16%
Unknown 14 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 30%
Agricultural and Biological Sciences 21 29%
Medicine and Dentistry 7 10%
Immunology and Microbiology 5 7%
Arts and Humanities 1 1%
Other 0 0%
Unknown 17 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2012.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Frontiers in immunology
#27,422
of 31,520 outputs
Outputs of similar age
#228,483
of 250,099 outputs
Outputs of similar age from Frontiers in immunology
#161
of 275 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,099 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 275 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.