Title |
Consequences of the crosstalk between monocytes/macrophages and natural killer cells
|
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Published in |
Frontiers in immunology, January 2013
|
DOI | 10.3389/fimmu.2012.00403 |
Pubmed ID | |
Authors |
Tatiana Michel, François Hentges, Jacques Zimmer |
Abstract |
The interaction between natural killer (NK) cells and different other immune cells like T cells and dendritic cells is well-described, but the crosstalk with monocytes or macrophages and the nature of ligands/receptors implicated are just emerging. The macrophage-NK interaction is a major first-line defense against pathogens (bacteria, viruses, fungi, and parasites). The recruitment and the activation of NK cells to perform cytotoxicity or produce cytokines at the sites of inflammation are important to fight infections. The two main mechanisms by which macrophages can prime NK cells are (1) activation through soluble mediators such as IL-12, IL-18, and (2) stimulation through direct cell-to-cell contact. We will discuss the progress in matters of modulation of NK cell functions by monocytes and macrophages, in the steady state and during diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 33% |
Switzerland | 1 | 33% |
United States | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 1% |
Israel | 1 | <1% |
Austria | 1 | <1% |
Unknown | 144 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 26% |
Researcher | 26 | 18% |
Student > Master | 23 | 16% |
Student > Bachelor | 12 | 8% |
Student > Doctoral Student | 10 | 7% |
Other | 20 | 14% |
Unknown | 19 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 41 | 28% |
Immunology and Microbiology | 38 | 26% |
Medicine and Dentistry | 23 | 16% |
Biochemistry, Genetics and Molecular Biology | 15 | 10% |
Linguistics | 2 | 1% |
Other | 7 | 5% |
Unknown | 22 | 15% |