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Functional complexity of the Leishmania granuloma and the potential of in silico modeling

Overview of attention for article published in Frontiers in immunology, January 2013
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  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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53 Mendeley
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Title
Functional complexity of the Leishmania granuloma and the potential of in silico modeling
Published in
Frontiers in immunology, January 2013
DOI 10.3389/fimmu.2013.00035
Pubmed ID
Authors

John W. J. Moore, Daniel Moyo, Lynette Beattie, Paul S. Andrews, Jon Timmis, Paul M. Kaye

Abstract

In human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development. However, it is unknown exactly how the granuloma microenvironment executes an effective antileishmanial response. Recent studies, including using advanced imaging techniques, have improved our understanding of granuloma biology at the cellular level, highlighting heterogeneity in granuloma development and function, and hinting at complex cellular, temporal, and spatial dynamics. In this mini-review, we discuss the factors involved in the formation and function of Leishmania donovani-induced hepatic granulomas, as well as their importance in protecting against inflammation-associated tissue damage and the generation of immunity to rechallenge. Finally, we discuss the role that computational, agent-based models may play in answering outstanding questions within the field.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 4%
United Kingdom 1 2%
Unknown 50 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 19%
Student > Ph. D. Student 9 17%
Researcher 8 15%
Student > Doctoral Student 6 11%
Professor 5 9%
Other 8 15%
Unknown 7 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 26%
Immunology and Microbiology 12 23%
Veterinary Science and Veterinary Medicine 7 13%
Medicine and Dentistry 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 3 6%
Unknown 12 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2016.
All research outputs
#14,937,796
of 25,411,814 outputs
Outputs from Frontiers in immunology
#13,230
of 31,614 outputs
Outputs of similar age
#169,421
of 289,120 outputs
Outputs of similar age from Frontiers in immunology
#146
of 503 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,614 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,120 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.