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MicroRNA regulation of natural killer cells

Overview of attention for article published in Frontiers in immunology, January 2013
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Title
MicroRNA regulation of natural killer cells
Published in
Frontiers in immunology, January 2013
DOI 10.3389/fimmu.2013.00044
Pubmed ID
Authors

Ryan P. Sullivan, Jeffrey W. Leong, Todd A. Fehniger

Abstract

Natural killer (NK) cells are innate immune lymphocytes critical for host defense against viral infection and surveillance against malignant transformation. MicroRNAs (miRNAs) are a family of small, non-coding RNAs that regulate a wide variety of cellular processes. Recent advances have highlighted the importance of miRNA-mediated post-transcriptional regulation in NK cell development, maturation, and function. This review focuses on several facets of this regulatory mechanism in NK cells: (1) the expressed NK cell miRNA transcriptome; (2) the impact of total miRNA deficiency on NK cells; (3) the role of specific miRNAs regulating NK cell development, survival, and maturation; (4) the intrinsic role of miRNAs regulating NK cell function, including cytokine production, proliferation, and cytotoxicity; and (5) the role of NK cell miRNAs in disease. Currently our knowledge of how miRNAs regulate NK cell biology is limited, and thus we also explore key open questions in the field, as well as approaches and techniques to ascertain the role of individual miRNAs as important molecular regulators.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Germany 1 1%
Austria 1 1%
Unknown 69 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 25%
Student > Ph. D. Student 16 22%
Student > Master 10 14%
Student > Doctoral Student 7 10%
Student > Bachelor 5 7%
Other 11 15%
Unknown 6 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 36%
Biochemistry, Genetics and Molecular Biology 13 18%
Immunology and Microbiology 11 15%
Medicine and Dentistry 9 12%
Computer Science 2 3%
Other 3 4%
Unknown 9 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2013.
All research outputs
#22,778,604
of 25,394,764 outputs
Outputs from Frontiers in immunology
#27,447
of 31,554 outputs
Outputs of similar age
#258,564
of 289,149 outputs
Outputs of similar age from Frontiers in immunology
#335
of 503 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,149 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.