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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A proposed role for neutrophil extracellular traps in cancer immunoediting
|
|---|---|
| Published in |
Frontiers in immunology, January 2013
|
| DOI | 10.3389/fimmu.2013.00048 |
| Pubmed ID | |
| Authors |
Sivan Berger-Achituv, Volker Brinkmann, Ulrike Abu Abed, Lars I. Kühn, Jonathan Ben-Ezra, Ronit Elhasid, Arturo Zychlinsky |
| Abstract |
Upon activation, neutrophils release fibers composed of chromatin and neutrophil proteins termed neutrophil extracellular traps (NETs). NETs trap and kill microbes, activate dendritic cells and T cells, and are implicated in autoimmune and vascular diseases. Given the growing interest in the role of neutrophils in cancer immunoediting and the diverse function of NETs, we searched for NETs release by tumor-associated neutrophils (TANs). Using pediatric Ewing sarcoma (ES) as a model, we retrospectively examined histopathological material from diagnostic biopsies of eight patients (mean ± SD age of 11.5 ± 4.7 years). TANs were found in six patients and in two of those we identified NETs. These two patients presented with metastatic disease and despite entering complete remission after intensive chemotherapy had an early relapse. NETs were not identified in the diagnostic biopsies of two patients with localized disease and two with metastatic disease. This study is the first to show that TANs in ES are activated to make NETs, pointing to a possible role of NETs in cancer. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| Poland | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 221 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 19% |
| Researcher | 34 | 15% |
| Student > Master | 26 | 12% |
| Student > Bachelor | 18 | 8% |
| Student > Doctoral Student | 16 | 7% |
| Other | 25 | 11% |
| Unknown | 63 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 49 | 22% |
| Medicine and Dentistry | 40 | 18% |
| Biochemistry, Genetics and Molecular Biology | 32 | 14% |
| Immunology and Microbiology | 26 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 1% |
| Other | 9 | 4% |
| Unknown | 66 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2014.
All research outputs
#16,721,717
of 25,374,647 outputs
Outputs from Frontiers in immunology
#18,323
of 31,520 outputs
Outputs of similar age
#187,801
of 289,004 outputs
Outputs of similar age from Frontiers in immunology
#192
of 503 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,004 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.