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Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load

Overview of attention for article published in Frontiers in immunology, January 2013
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Title
Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load
Published in
Frontiers in immunology, January 2013
DOI 10.3389/fimmu.2013.00086
Pubmed ID
Authors

Luca Genovese, Manuela Nebuloni, Massimo Alfano

Abstract

The natural course of human immunodeficiency virus (HIV) infection is characterized by high viral load, depletion of immune cells, and immunodeficiency, ultimately leading to acquired immunodeficiency syndrome phase and the occurrence of opportunistic infections and diseases. Since the discovery of HIV in the early 1980s a naturally selected population of infected individuals has been emerged in the last years, characterized by being infected for many years, with viremia constantly below detectable level and poor depletion of immune cells. These individuals are classified as "elite controllers (EC) or suppressors" and do not develop disease in the absence of anti-retroviral therapy. Unveiling host factors and immune responses responsible for the elite status will likely provide clues for the design of therapeutic vaccines and functional cures. Scope of this review was to examine and discuss differences of the cell-mediated immune responses between HIV+ individuals with disease progression and EC.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
South Africa 1 1%
United Kingdom 1 1%
Argentina 1 1%
United States 1 1%
Unknown 73 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 22%
Researcher 15 19%
Student > Master 9 12%
Student > Bachelor 9 12%
Student > Doctoral Student 7 9%
Other 10 13%
Unknown 11 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 32%
Medicine and Dentistry 20 26%
Biochemistry, Genetics and Molecular Biology 8 10%
Immunology and Microbiology 8 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 3 4%
Unknown 13 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2013.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Frontiers in immunology
#27,422
of 31,520 outputs
Outputs of similar age
#258,419
of 289,007 outputs
Outputs of similar age from Frontiers in immunology
#335
of 503 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.