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New Insights in the Immunobiology of IL-1 Family Members

Overview of attention for article published in Frontiers in immunology, January 2013
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Title
New Insights in the Immunobiology of IL-1 Family Members
Published in
Frontiers in immunology, January 2013
DOI 10.3389/fimmu.2013.00167
Pubmed ID
Authors

Frank L. van de Veerdonk, Mihai G. Netea

Abstract

The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection. The biological properties of IL 1 family ligands are typically pro-inflammatory. The IL 1 family has 11 family members and can be categorized into subfamilies according to the length of their precursor and the length of the propiece for each precursor (Figure 1). The IL 1 subfamily consists of IL 1α, IL 1β, and IL 33, with the longest propieces of the IL 1 family. IL 18 and IL 37 belong to the IL 18 subfamily and contain smaller propieces than IL 1 and IL-33. Since IL 37 binds to the IL 18Rα chain it is part of the IL 18 subfamily, however it remains to be elucidated how the propiece of IL 37 is removed. IL 36α, β, and γ as well as IL 36 Ra belong to the IL 36 subfamily. In addition, IL 38 likely belongs to this family since it has the ability to bind to the IL 36R. The IL 36 subfamily has the shortest propiece. The one member of the IL 1 family that cannot be categorized in these subfamilies is IL 1 receptor antagonist (IL 1Ra), which has a signal peptide and is readily secreted. In the present review we will describe the biological functions of the IL-1F members and new insights in their biology.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
Portugal 1 <1%
Unknown 148 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 19%
Researcher 28 19%
Student > Master 16 11%
Student > Doctoral Student 15 10%
Student > Bachelor 13 9%
Other 23 15%
Unknown 26 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 33%
Medicine and Dentistry 33 22%
Biochemistry, Genetics and Molecular Biology 15 10%
Immunology and Microbiology 14 9%
Business, Management and Accounting 1 <1%
Other 8 5%
Unknown 29 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2014.
All research outputs
#14,915,476
of 25,374,917 outputs
Outputs from Frontiers in immunology
#13,191
of 31,520 outputs
Outputs of similar age
#169,313
of 289,007 outputs
Outputs of similar age from Frontiers in immunology
#146
of 503 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.