Title |
The Effect of Age on Thymic Function
|
---|---|
Published in |
Frontiers in immunology, January 2013
|
DOI | 10.3389/fimmu.2013.00316 |
Pubmed ID | |
Authors |
Donald B. Palmer |
Abstract |
Age-related regression of the thymus is associated with a decline in naïve T cell output. This is thought to contribute to the reduction in T cell diversity seen in older individuals and linked with increased susceptibility to infection, autoimmune disease, and cancer. Thymic involution is one of the most dramatic and ubiquitous changes seen in the aging immune system, but the mechanisms which underlying this process are poorly understood. However, a picture is emerging, implicating the involvement of both extrinsic and intrinsic factors. In this review we assess the role of the thymic microenvironment as a potential target that regulates thymic involution, question whether thymocyte development in the aged thymus is functionally impaired, and explore the kinetics of thymic involution. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 27% |
Germany | 1 | 9% |
Australia | 1 | 9% |
United Kingdom | 1 | 9% |
Canada | 1 | 9% |
Switzerland | 1 | 9% |
Unknown | 3 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 91% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Japan | 2 | <1% |
France | 1 | <1% |
Portugal | 1 | <1% |
Austria | 1 | <1% |
Unknown | 379 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 73 | 19% |
Student > Bachelor | 57 | 15% |
Student > Master | 53 | 14% |
Researcher | 42 | 11% |
Student > Doctoral Student | 18 | 5% |
Other | 61 | 16% |
Unknown | 82 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 64 | 17% |
Biochemistry, Genetics and Molecular Biology | 60 | 16% |
Immunology and Microbiology | 58 | 15% |
Medicine and Dentistry | 57 | 15% |
Unspecified | 12 | 3% |
Other | 36 | 9% |
Unknown | 99 | 26% |