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Hiding in Plain Sight: Interplay between Staphylococcal Biofilms and Host Immunity

Overview of attention for article published in Frontiers in immunology, January 2014
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Title
Hiding in Plain Sight: Interplay between Staphylococcal Biofilms and Host Immunity
Published in
Frontiers in immunology, January 2014
DOI 10.3389/fimmu.2014.00037
Pubmed ID
Authors

Tyler D. Scherr, Cortney E. Heim, John M. Morrison, Tammy Kielian

Abstract

Staphylococcus aureus and Staphylococcus epidermidis are notable for their propensity to form biofilms on implanted medical devices. Staphylococcal biofilm infections are typified by their recalcitrance to antibiotics and ability to circumvent host immune-mediated clearance, resulting in the establishment of chronic infections that are often recurrent in nature. Indeed, the immunomodulatory lifestyle of biofilms seemingly shapes the host immune response to ensure biofilm engraftment and persistence in an immune competent host. Here, we provide a brief review of the mechanisms whereby S. aureus and S. epidermidis biofilms manipulate host-pathogen interactions and discuss the concept of microenvironment maintenance in infectious outcomes, as well as speculate how these findings pertain to the challenges of staphylococcal vaccine development.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
United Kingdom 1 <1%
Thailand 1 <1%
Switzerland 1 <1%
Unknown 188 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 24%
Researcher 29 15%
Student > Bachelor 26 13%
Student > Master 21 11%
Student > Doctoral Student 13 7%
Other 23 12%
Unknown 34 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 24%
Immunology and Microbiology 36 19%
Biochemistry, Genetics and Molecular Biology 28 15%
Medicine and Dentistry 26 13%
Veterinary Science and Veterinary Medicine 7 4%
Other 13 7%
Unknown 37 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2014.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Frontiers in immunology
#27,421
of 31,520 outputs
Outputs of similar age
#280,467
of 319,281 outputs
Outputs of similar age from Frontiers in immunology
#69
of 97 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,281 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.