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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics
|
|---|---|
| Published in |
Frontiers in immunology, January 2014
|
| DOI | 10.3389/fimmu.2014.00060 |
| Pubmed ID | |
| Authors |
Sander de Kivit, Mary C. Tobin, Christopher B. Forsyth, Ali Keshavarzian, Alan L. Landay |
| Abstract |
The intestinal mucosa is constantly facing a high load of antigens including bacterial antigens derived from the microbiota and food. Despite this, the immune cells present in the gastrointestinal tract do not initiate a pro-inflammatory immune response. Toll-like receptors (TLRs) are pattern recognition receptors expressed by various cells in the gastrointestinal tract, including intestinal epithelial cells (IEC) and resident immune cells in the lamina propria. Many diseases, including chronic intestinal inflammation (e.g., inflammatory bowel disease), irritable bowel syndrome (IBS), allergic gastroenteritis (e.g., eosinophilic gastroenteritis and allergic IBS), and infections are nowadays associated with a deregulated microbiota. The microbiota may directly interact with TLR. In addition, differences in intestinal TLR expression in health and disease may suggest that TLRs play an essential role in disease pathogenesis and may be novel targets for therapy. TLR signaling in the gut is involved in either maintaining intestinal homeostasis or the induction of an inflammatory response. This mini review provides an overview of the current knowledge regarding the contribution of intestinal epithelial TLR signaling in both tolerance induction or promoting intestinal inflammation, with a focus on food allergy. We will also highlight a potential role of the microbiota in regulating gut immune responses, especially through TLR activation. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 257 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | <1% |
| France | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Brazil | 1 | <1% |
| Denmark | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 249 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 47 | 18% |
| Researcher | 34 | 13% |
| Student > Ph. D. Student | 34 | 13% |
| Student > Bachelor | 32 | 12% |
| Student > Doctoral Student | 13 | 5% |
| Other | 47 | 18% |
| Unknown | 50 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 81 | 32% |
| Medicine and Dentistry | 42 | 16% |
| Biochemistry, Genetics and Molecular Biology | 20 | 8% |
| Immunology and Microbiology | 20 | 8% |
| Nursing and Health Professions | 8 | 3% |
| Other | 21 | 8% |
| Unknown | 65 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#1,786,995
of 25,654,806 outputs
Outputs from Frontiers in immunology
#1,630
of 32,130 outputs
Outputs of similar age
#19,595
of 320,719 outputs
Outputs of similar age from Frontiers in immunology
#4
of 97 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,130 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.