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Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells

Overview of attention for article published in Frontiers in immunology, March 2014
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Title
Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells
Published in
Frontiers in immunology, March 2014
DOI 10.3389/fimmu.2014.00092
Pubmed ID
Authors

Ana M. Avalos, Hidde L. Ploegh

Abstract

B cells are efficient antigen-presenting cells (APCs), relying on antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also initiate B cell responses. In this review, we describe the steps required for antigen uptake, processing, and loading of peptides onto MHC Class II compartments in B cells for efficient presentation to CD4 T cells, with a special focus in the initial steps of BCR recognition of antigen.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 241 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 2 <1%
Peru 1 <1%
Switzerland 1 <1%
Unknown 237 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 71 29%
Researcher 40 17%
Student > Master 32 13%
Student > Bachelor 22 9%
Student > Doctoral Student 15 6%
Other 24 10%
Unknown 37 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 62 26%
Immunology and Microbiology 54 22%
Biochemistry, Genetics and Molecular Biology 37 15%
Medicine and Dentistry 22 9%
Chemistry 5 2%
Other 18 7%
Unknown 43 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2014.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Frontiers in immunology
#27,421
of 31,520 outputs
Outputs of similar age
#205,412
of 235,363 outputs
Outputs of similar age from Frontiers in immunology
#78
of 95 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,363 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.