Title |
Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored
|
---|---|
Published in |
Frontiers in immunology, March 2014
|
DOI | 10.3389/fimmu.2014.00102 |
Pubmed ID | |
Authors |
Luis de la Cruz-Merino, Ana Illescas-Vacas, Ana Grueso-López, Antonio Barco-Sánchez, Carlos Míguez-Sánchez, Cancer Immunotherapies Spanish Group |
Abstract |
Recent advances that have been made in our understanding of cancer biology and immunology show that infiltrated immune cells and cytokines in the tumor microenvironment may play different functions that appear tightly related to clinical outcomes. Strategies aimed at interfering with the cross-talk between microenvironment tumor cells and their cellular partners have been considered for the development of new immunotherapies. These novel therapies target different cell components of the tumor microenvironment and importantly, they may be coupled and boosted with classical treatments, such as radiotherapy. In this work, we try to summarize recent data on the microenvironment impact of radiation therapy, from pre-clinical research to the clinic, while taking into account that this new knowledge will probably translate into indication and objective of radiation therapy changes in the next future. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 67% |
Switzerland | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 4% |
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Switzerland | 1 | 2% |
Unknown | 49 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 17% |
Student > Master | 9 | 17% |
Other | 8 | 15% |
Student > Ph. D. Student | 7 | 13% |
Professor > Associate Professor | 4 | 7% |
Other | 10 | 19% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 41% |
Agricultural and Biological Sciences | 9 | 17% |
Immunology and Microbiology | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Physics and Astronomy | 3 | 6% |
Other | 3 | 6% |
Unknown | 9 | 17% |