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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Bacterial Outer Membrane Vesicles and Vaccine Applications
|
|---|---|
| Published in |
Frontiers in immunology, March 2014
|
| DOI | 10.3389/fimmu.2014.00121 |
| Pubmed ID | |
| Authors |
Reinaldo Acevedo, Sonsire Fernández, Caridad Zayas, Armando Acosta, Maria Elena Sarmiento, Valerie A. Ferro, Einar Rosenqvist, Concepcion Campa, Daniel Cardoso, Luis Garcia, Jose Luis Perez |
| Abstract |
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of meningococcal antigens or unrelated antigens incorporated into the vesicle structure. This paper reviews different applications in OMV Research and Development (R&D) and provides examples of OMV developed and evaluated at the Finlay Institute in Cuba. A Good Manufacturing Practice (GMP) process was developed at the Finlay Institute to produce OMV from N. meningitidis serogroup B (dOMVB) using detergent extraction. Subsequently, OMV from N. meningitidis, serogroup A (dOMVA), serogroup W (dOMVW), and serogroup X (dOMVX) were obtained using this process. More recently, the extraction process has also been applied effectively for obtaining OMV on a research scale from Vibrio cholerae (dOMVC), Bordetella pertussis (dOMVBP), Mycobacterium smegmatis (dOMVSM), and BCG (dOMVBCG). The immunogenicity of the OMV has been evaluated for specific antibody induction, and together with functional bactericidal and challenge assays in mice has shown their protective potential. dOMVB has been evaluated with non-neisserial antigens, including with a herpes virus type 2 glycoprotein, ovalbumin, and allergens. In conclusion, OMV are proving to be more versatile than first conceived and remain an important technology for development of vaccine candidates. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 318 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Israel | 1 | <1% |
| Slovenia | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 311 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 17% |
| Student > Master | 49 | 15% |
| Researcher | 44 | 14% |
| Student > Bachelor | 41 | 13% |
| Student > Doctoral Student | 21 | 7% |
| Other | 39 | 12% |
| Unknown | 70 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 69 | 22% |
| Agricultural and Biological Sciences | 65 | 20% |
| Immunology and Microbiology | 45 | 14% |
| Medicine and Dentistry | 13 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 3% |
| Other | 39 | 12% |
| Unknown | 76 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2023.
All research outputs
#2,813,793
of 25,394,764 outputs
Outputs from Frontiers in immunology
#2,899
of 31,554 outputs
Outputs of similar age
#27,538
of 237,053 outputs
Outputs of similar age from Frontiers in immunology
#6
of 106 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,053 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.