Title |
Gut Microbiota and the Paradox of Cancer Immunotherapy
|
---|---|
Published in |
Frontiers in immunology, April 2014
|
DOI | 10.3389/fimmu.2014.00157 |
Pubmed ID | |
Authors |
Theofilos Poutahidis, Markus Kleinewietfeld, Susan E. Erdman |
Abstract |
It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | <1% |
France | 1 | <1% |
Italy | 1 | <1% |
India | 1 | <1% |
United States | 1 | <1% |
Unknown | 97 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 22% |
Student > Ph. D. Student | 18 | 18% |
Student > Master | 11 | 11% |
Student > Bachelor | 9 | 9% |
Student > Postgraduate | 8 | 8% |
Other | 25 | 25% |
Unknown | 9 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 30 | 29% |
Medicine and Dentistry | 22 | 22% |
Biochemistry, Genetics and Molecular Biology | 15 | 15% |
Immunology and Microbiology | 12 | 12% |
Engineering | 3 | 3% |
Other | 6 | 6% |
Unknown | 14 | 14% |