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Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy

Overview of attention for article published in Frontiers in immunology, May 2014
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Title
Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy
Published in
Frontiers in immunology, May 2014
DOI 10.3389/fimmu.2014.00253
Pubmed ID
Authors

Piyali Chatterjee, Valorie L. Chiasson, Kelsey R. Bounds, Brett M. Mitchell

Abstract

Inflammation mediated by both innate and adaptive immune cells is necessary for several important processes during pregnancy. Pro-inflammatory immune cell activation plays a critical role in embryo implantation, placentation, and parturition; however dysregulation of these cells can lead to detrimental pregnancy outcomes including spontaneous abortion, fetal growth restriction, maternal pathology including hypertensive disorders, or fetal and maternal death. The resolution of inflammation plays an important role throughout pregnancy and is largely mediated by immune cells that produce interleukin (IL)-4 and IL-10. The temporal and spatial aspects of reducing inflammation during pregnancy represent a complex process that if not functioning optimally can lead to persistent inflammation and pregnancy complications. In this review, we examine how immune cells that produce IL-4 and IL-10 are regulated throughout pregnancy as well as the effects that reduced IL-4 and IL-10 signaling has on fetal and maternal physiology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 278 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 <1%
Ukraine 1 <1%
Spain 1 <1%
Unknown 274 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 17%
Student > Master 37 13%
Student > Bachelor 35 13%
Researcher 28 10%
Student > Doctoral Student 18 6%
Other 38 14%
Unknown 76 27%
Readers by discipline Count As %
Medicine and Dentistry 46 17%
Agricultural and Biological Sciences 34 12%
Biochemistry, Genetics and Molecular Biology 34 12%
Immunology and Microbiology 22 8%
Pharmacology, Toxicology and Pharmaceutical Science 12 4%
Other 34 12%
Unknown 96 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2016.
All research outputs
#20,674,485
of 25,394,764 outputs
Outputs from Frontiers in immunology
#24,770
of 31,554 outputs
Outputs of similar age
#177,302
of 241,486 outputs
Outputs of similar age from Frontiers in immunology
#96
of 131 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,486 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.