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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dendritic Cell-Targeted Vaccines
|
|---|---|
| Published in |
Frontiers in immunology, May 2014
|
| DOI | 10.3389/fimmu.2014.00255 |
| Pubmed ID | |
| Authors |
Lillian Cohn, Lélia Delamarre |
| Abstract |
Despite significant effort, the development of effective vaccines inducing strong and durable T-cell responses against intracellular pathogens and cancer cells has remained a challenge. The initiation of effector CD8(+) T-cell responses requires the presentation of peptides derived from internalized antigen on class I major histocompatibility complex molecules by dendritic cells (DCs) in a process called cross-presentation. A current strategy to enhance the effectiveness of vaccination is to deliver antigens directly to DCs. This is done via selective targeting of antigen using monoclonal antibodies directed against endocytic receptors on the surface of the DCs. In this review, we will discuss considerations relevant to the design of such vaccines: the existence of DC subsets with specialized functions, the impact of the antigen intracellular trafficking on cross-presentation, and the influence of maturation signals received by DCs on the outcome of the immune response. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Taiwan | 1 | 9% |
| Germany | 1 | 9% |
| United States | 1 | 9% |
| Mexico | 1 | 9% |
| Switzerland | 1 | 9% |
| United Kingdom | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 73% |
| Scientists | 2 | 18% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 277 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| Singapore | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Belgium | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 269 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 65 | 23% |
| Student > Master | 48 | 17% |
| Researcher | 44 | 16% |
| Student > Bachelor | 31 | 11% |
| Other | 14 | 5% |
| Other | 34 | 12% |
| Unknown | 41 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 77 | 28% |
| Immunology and Microbiology | 60 | 22% |
| Medicine and Dentistry | 35 | 13% |
| Biochemistry, Genetics and Molecular Biology | 27 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 3% |
| Other | 25 | 9% |
| Unknown | 44 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2016.
All research outputs
#2,291,046
of 25,374,917 outputs
Outputs from Frontiers in immunology
#2,224
of 31,520 outputs
Outputs of similar age
#22,292
of 240,672 outputs
Outputs of similar age from Frontiers in immunology
#6
of 135 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,672 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.