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CD8+ T-Cell Responses in Acute Hepatitis C Virus Infection

Overview of attention for article published in Frontiers in immunology, June 2014
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  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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Title
CD8+ T-Cell Responses in Acute Hepatitis C Virus Infection
Published in
Frontiers in immunology, June 2014
DOI 10.3389/fimmu.2014.00266
Pubmed ID
Authors

Pil Soo Sung, Vito Racanelli, Eui-Cheol Shin

Abstract

Hepatitis C virus (HCV) infects approximately 170 million people worldwide and is a major cause of life-threatening liver diseases such as liver cirrhosis and hepatocellular carcinoma. Acute HCV infection often progresses to chronic persistent infection, although some patients recover spontaneously. The divergent outcomes of acute HCV infection are known to be determined by differences in virus-specific T-cell responses among patients. Of the two major T-cell subsets, CD8(+) T-cells are known to be the key effector cells that control viral infections via cytolytic activity and cytokine secretion. Herein, we review various aspects of HCV-specific CD8(+) T-cell responses in acute HCV infection. In particular, we focus on timing of CD8(+) T-cell responses, relationship between CD8(+) T-cell responses and outcomes of acute HCV infection, receptor expression on CD8(+) T-cells, breadth of CD8(+) T-cell responses, and viral mutations.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 2%
India 1 2%
Russia 1 2%
Unknown 52 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 22%
Student > Bachelor 10 18%
Researcher 7 13%
Student > Master 7 13%
Student > Doctoral Student 5 9%
Other 8 15%
Unknown 6 11%
Readers by discipline Count As %
Immunology and Microbiology 16 29%
Medicine and Dentistry 13 24%
Agricultural and Biological Sciences 9 16%
Biochemistry, Genetics and Molecular Biology 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 5 9%
Unknown 7 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2014.
All research outputs
#15,091,901
of 25,374,647 outputs
Outputs from Frontiers in immunology
#13,910
of 31,520 outputs
Outputs of similar age
#122,067
of 242,856 outputs
Outputs of similar age from Frontiers in immunology
#41
of 136 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,856 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.