Title |
Organ-Specific and Memory Treg Cells: Specificity, Development, Function, and Maintenance
|
---|---|
Published in |
Frontiers in immunology, July 2014
|
DOI | 10.3389/fimmu.2014.00333 |
Pubmed ID | |
Authors |
Iris K. Gratz, Daniel J. Campbell |
Abstract |
Foxp3(+) regulatory T cells (Treg cells) are essential for establishing and maintaining self-tolerance, and also inhibit immune responses to innocuous environmental antigens. Imbalances and dysfunction in Treg cells lead to a variety of immune-mediated diseases, as deficits in Treg cell function contribute to the development autoimmune disease and pathological tissue damage, whereas overabundance of Treg cells can promote chronic infection and tumorigenesis. Recent studies have highlighted the fact that Treg cells themselves are a diverse collection of phenotypically and functionally specialized populations, with distinct developmental origins, antigen-specificities, tissue-tropisms, and homeostatic requirements. The signals directing the differentiation of these populations, their specificities and the mechanisms by which they combine to promote organ-specific and systemic tolerance, and how they embody the emerging property of regulatory memory are the focus of this review. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Hungary | 1 | <1% |
Italy | 1 | <1% |
Germany | 1 | <1% |
Mexico | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 157 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 46 | 28% |
Researcher | 24 | 15% |
Student > Master | 16 | 10% |
Student > Bachelor | 15 | 9% |
Student > Doctoral Student | 8 | 5% |
Other | 34 | 21% |
Unknown | 21 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 30% |
Medicine and Dentistry | 32 | 20% |
Immunology and Microbiology | 26 | 16% |
Biochemistry, Genetics and Molecular Biology | 21 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
Other | 6 | 4% |
Unknown | 27 | 16% |