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Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications

Overview of attention for article published in Frontiers in immunology, August 2014
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  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Title
Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications
Published in
Frontiers in immunology, August 2014
DOI 10.3389/fimmu.2014.00354
Pubmed ID
Authors

Zsuzsa Szondy, Éva Garabuczi, Gergely Joós, Gregory J. Tsay, Zsolt Sarang

Abstract

In healthy individuals, billions of cells die by apoptosis every day. Removal of the dead cells by phagocytosis (a process called efferocytosis) must be efficient to prevent secondary necrosis and the consequent release of pro-inflammatory cell contents that damages the tissue environment and provokes autoimmunity. In addition, detection and removal of apoptotic cells generally induces an anti-inflammatory response. As a consequence improper clearance of apoptotic cells, being the result of either genetic anomalies and/or a persistent disease state, contributes to the establishment and progression of a number of human chronic inflammatory diseases such as autoimmune and neurological disorders, inflammatory lung diseases, obesity, type 2 diabetes, or atherosclerosis. During the past decade, our knowledge about the mechanism of efferocytosis has significantly increased, providing therapeutic targets through which impaired phagocytosis of apoptotic cells and the consequent inflammation could be influenced in these diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Colombia 1 <1%
United States 1 <1%
Unknown 116 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 24%
Student > Master 14 12%
Researcher 13 11%
Student > Bachelor 11 9%
Other 7 6%
Other 20 17%
Unknown 26 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 19%
Biochemistry, Genetics and Molecular Biology 19 16%
Immunology and Microbiology 13 11%
Medicine and Dentistry 13 11%
Neuroscience 4 3%
Other 17 14%
Unknown 30 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2014.
All research outputs
#14,928,462
of 25,394,764 outputs
Outputs from Frontiers in immunology
#13,200
of 31,554 outputs
Outputs of similar age
#116,912
of 240,282 outputs
Outputs of similar age from Frontiers in immunology
#53
of 140 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.