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Small and Long Regulatory RNAs in the Immune System and Immune Diseases

Overview of attention for article published in Frontiers in immunology, October 2014
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Title
Small and Long Regulatory RNAs in the Immune System and Immune Diseases
Published in
Frontiers in immunology, October 2014
DOI 10.3389/fimmu.2014.00513
Pubmed ID
Authors

Anna Stachurska, Maria M. Zorro, Marijke R. van der Sijde, Sebo Withoff

Abstract

Cellular differentiation is regulated on the level of gene expression, and it is known that dysregulation of gene expression can lead to deficiencies in differentiation that contribute to a variety of diseases, particularly of the immune system. Until recently, it was thought that the dysregulation was governed by changes in the binding or activity of a class of proteins called transcription factors. However, the discovery of micro-RNAs and recent descriptions of long non-coding RNAs (lncRNAs) have given enormous momentum to a whole new field of biology: the regulatory RNAs. In this review, we describe these two classes of regulatory RNAs and summarize what is known about how they regulate aspects of the adaptive and innate immune systems. Finally, we describe what is known about the involvement of micro-RNAs and lncRNAs in three different autoimmune diseases (celiac disease, inflammatory bowel disease, and multiple sclerosis).

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Netherlands 1 1%
Colombia 1 1%
Denmark 1 1%
Unknown 74 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 26%
Researcher 13 17%
Student > Master 13 17%
Student > Doctoral Student 6 8%
Student > Bachelor 5 6%
Other 11 14%
Unknown 10 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 31%
Biochemistry, Genetics and Molecular Biology 20 26%
Medicine and Dentistry 13 17%
Immunology and Microbiology 6 8%
Computer Science 1 1%
Other 2 3%
Unknown 12 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2014.
All research outputs
#19,962,154
of 25,394,764 outputs
Outputs from Frontiers in immunology
#22,598
of 31,554 outputs
Outputs of similar age
#187,738
of 272,459 outputs
Outputs of similar age from Frontiers in immunology
#130
of 187 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,459 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 187 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.