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“Small Talk” in the Innate Immune System via RNA-Containing Extracellular Vesicles

Overview of attention for article published in Frontiers in immunology, October 2014
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115 Mendeley
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Title
“Small Talk” in the Innate Immune System via RNA-Containing Extracellular Vesicles
Published in
Frontiers in immunology, October 2014
DOI 10.3389/fimmu.2014.00542
Pubmed ID
Authors

Susanne G. van der Grein, Esther N. M. Nolte-’t Hoen

Abstract

A newly uncovered means of communication between cells involves intercellular transfer of nano-sized extracellular vesicles (EV), composed of lipids, proteins, and genetic material. EV released by cells of the immune system can play a regulatory role in the induction and suppression of immune responses. These functions may be mediated not only by the bioactive lipids and proteins present in EV but also by EV-associated RNAs. The RNA in EV mainly consists of microRNAs and a large range of other small non-coding RNA species. Since many of these small RNAs have the potential to regulate gene expression, intercellular transfer of these RNAs via EV may cause long-term changes in the function of EV-targeted cells. Several types of innate immune cells release EV that affect innate immune responses and other (patho)physiological processes. Additionally, the innate immune system is influenced by EV released by non-immune cells and EV found in body fluids. In this review, we focus on how EV-associated RNAs contribute to these immune regulatory processes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 <1%
Switzerland 1 <1%
Unknown 113 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 26%
Researcher 28 24%
Student > Bachelor 11 10%
Student > Master 10 9%
Student > Doctoral Student 9 8%
Other 13 11%
Unknown 14 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 41%
Biochemistry, Genetics and Molecular Biology 21 18%
Medicine and Dentistry 12 10%
Immunology and Microbiology 11 10%
Chemistry 3 3%
Other 5 4%
Unknown 16 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2014.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Frontiers in immunology
#20,300
of 31,520 outputs
Outputs of similar age
#164,796
of 274,447 outputs
Outputs of similar age from Frontiers in immunology
#124
of 186 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,447 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.