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NKT Cell Networks in the Regulation of Tumor Immunity

Overview of attention for article published in Frontiers in immunology, October 2014
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

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Title
NKT Cell Networks in the Regulation of Tumor Immunity
Published in
Frontiers in immunology, October 2014
DOI 10.3389/fimmu.2014.00543
Pubmed ID
Authors

Faith C. Robertson, Jay A. Berzofsky, Masaki Terabe

Abstract

CD1d-restricted natural killer T (NKT) cells lie at the interface between the innate and adaptive immune systems and are important mediators of immune responses and tumor immunosurveillance. These NKT cells uniquely recognize lipid antigens, and their rapid yet specific reactions influence both innate and adaptive immunity. In tumor immunity, two NKT subsets (type I and type II) have contrasting roles in which they not only cross-regulate one another, but also impact innate immune cell populations, including natural killer, dendritic, and myeloid lineage cells, as well as adaptive populations, especially CD8(+) and CD4(+) T cells. The extent to which NKT cells promote or suppress surrounding cells affects the host's ability to prevent neoplasia and is consequently of great interest for therapeutic development. Data have shown the potential for therapeutic use of NKT cell agonists and synergy with immune response modifiers in both pre-clinical studies and preliminary clinical studies. However, there is room to improve treatment efficacy by further elucidating the biological mechanisms underlying NKT cell networks. Here, we discuss the progress made in understanding NKT cell networks, their consequent role in the regulation of tumor immunity, and the potential to exploit that knowledge in a clinical setting.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Switzerland 1 <1%
South Africa 1 <1%
Canada 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 193 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 38 19%
Student > Ph. D. Student 32 16%
Student > Master 27 14%
Student > Bachelor 23 12%
Student > Doctoral Student 19 10%
Other 31 16%
Unknown 29 15%
Readers by discipline Count As %
Immunology and Microbiology 47 24%
Agricultural and Biological Sciences 47 24%
Biochemistry, Genetics and Molecular Biology 29 15%
Medicine and Dentistry 28 14%
Chemistry 6 3%
Other 4 2%
Unknown 38 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2021.
All research outputs
#7,356,343
of 25,374,647 outputs
Outputs from Frontiers in immunology
#8,557
of 31,520 outputs
Outputs of similar age
#76,623
of 274,082 outputs
Outputs of similar age from Frontiers in immunology
#56
of 186 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,082 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.