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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Erythropoietin and Cancer: The Unintended Consequences of Anemia Correction
|
|---|---|
| Published in |
Frontiers in immunology, November 2014
|
| DOI | 10.3389/fimmu.2014.00563 |
| Pubmed ID | |
| Authors |
Nataša Debeljak, Peter Solár, Arthur J. Sytkowski |
| Abstract |
Until 1990, erythropoietin (EPO) was considered to have a single biological purpose and action, the stimulation of red blood cell growth and differentiation. Slowly, scientific and medical opinion evolved, beginning with the discovery of an effect on endothelial cell growth in vitro and the identification of EPO receptors (EPORs) on neuronal cells. We now know that EPO is a pleiotropic growth factor that exhibits an anti-apoptotic action on numerous cells and tissues, including malignant ones. In this article, we present a short discussion of EPO, receptors involved in EPO signal transduction, and their action on non-hematopoietic cells. This is followed by a more detailed presentation of both pre-clinical and clinical data that demonstrate EPO's action on cancer cells, as well as tumor angiogenesis and lymphangiogenesis. Clinical trials with reported adverse effects of chronic erythropoiesis-stimulating agents (ESAs) treatment as well as clinical studies exploring the prognostic significance of EPO and EPOR expression in cancer patients are reviewed. Finally, we address the use of EPO and other ESAs in cancer patients. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 16% |
| Taiwan | 1 | 5% |
| Turkey | 1 | 5% |
| Argentina | 1 | 5% |
| Guatemala | 1 | 5% |
| Switzerland | 1 | 5% |
| Unknown | 11 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 63% |
| Practitioners (doctors, other healthcare professionals) | 4 | 21% |
| Scientists | 2 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 96 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 13% |
| Student > Master | 12 | 12% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Doctoral Student | 10 | 10% |
| Other | 8 | 8% |
| Other | 22 | 23% |
| Unknown | 21 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 29% |
| Agricultural and Biological Sciences | 17 | 18% |
| Biochemistry, Genetics and Molecular Biology | 11 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Nursing and Health Professions | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 23 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2022.
All research outputs
#3,247,157
of 25,411,814 outputs
Outputs from Frontiers in immunology
#3,471
of 31,614 outputs
Outputs of similar age
#36,306
of 271,194 outputs
Outputs of similar age from Frontiers in immunology
#23
of 183 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,614 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,194 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 183 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.