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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics
|
|---|---|
| Published in |
Frontiers in immunology, January 2015
|
| DOI | 10.3389/fimmu.2014.00682 |
| Pubmed ID | |
| Authors |
Kine Marita Knudsen Sand, Malin Bern, Jeannette Nilsen, Hanna Theodora Noordzij, Inger Sandlie, Jan Terje Andersen |
| Abstract |
The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism. However, it has now become apparent that the same receptor also binds albumin and plays a fundamental role in homeostatic regulation of both IgG and albumin, as FcRn is expressed in many different cell types and organs at diverse body sites. Thus, to gain a complete understanding of the biological function of each ligand, and also their distribution in the body, an in-depth characterization of how FcRn binds and regulates the transport of both ligands is necessary. Importantly, such knowledge is also relevant when developing new drugs, as IgG and albumin are increasingly utilized in therapy. This review discusses our current structural and biological understanding of the relationship between FcRn and its ligands, with a particular focus on albumin and design of albumin-based therapeutics. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 394 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Austria | 1 | <1% |
| Czechia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Denmark | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 386 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 79 | 20% |
| Researcher | 67 | 17% |
| Student > Master | 43 | 11% |
| Student > Bachelor | 37 | 9% |
| Student > Doctoral Student | 22 | 6% |
| Other | 54 | 14% |
| Unknown | 92 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 66 | 17% |
| Biochemistry, Genetics and Molecular Biology | 63 | 16% |
| Chemistry | 43 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 33 | 8% |
| Medicine and Dentistry | 24 | 6% |
| Other | 65 | 16% |
| Unknown | 100 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2021.
All research outputs
#4,431,695
of 25,655,374 outputs
Outputs from Frontiers in immunology
#4,845
of 32,129 outputs
Outputs of similar age
#58,097
of 361,842 outputs
Outputs of similar age from Frontiers in immunology
#22
of 169 outputs
Altmetric has tracked 25,655,374 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,129 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.