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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Citrullination and Carbamylation in the Pathophysiology of Rheumatoid Arthritis
|
|---|---|
| Published in |
Frontiers in immunology, April 2015
|
| DOI | 10.3389/fimmu.2015.00192 |
| Pubmed ID | |
| Authors |
Ger J. M. Pruijn |
| Abstract |
The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis (RA) had a huge impact on studies aimed at understanding autoimmunity in this disease. In addition to the detailed characterization of anti-citrullinated protein antibodies, various studies have addressed the identity of citrullinated antigens. These investigations were facilitated by new methods to characterize these proteins, the analysis of protein citrullination by peptidylarginine deiminases, the generation of a catalog of citrullinated proteins present in the inflamed joints of patients and the finding that the formation of extracellular traps is dependent on the activity of peptidylarginine deiminase activity. Recently, it was found that in addition to citrullination also carbamylation, which results in chemically highly related modified proteins, yields antigens that are targeted by rheumatoid arthritis patient sera. Here, all of these aspects will be discussed, culminating in current ideas about the involvement of citrullination and carbamylation in pathophysiological processes in autoimmunity, especially RA. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 33% |
| United States | 1 | 33% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 153 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 19% |
| Student > Ph. D. Student | 26 | 17% |
| Student > Bachelor | 23 | 15% |
| Student > Master | 12 | 8% |
| Other | 10 | 6% |
| Other | 28 | 18% |
| Unknown | 27 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 19% |
| Biochemistry, Genetics and Molecular Biology | 29 | 19% |
| Immunology and Microbiology | 23 | 15% |
| Agricultural and Biological Sciences | 18 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 16 | 10% |
| Unknown | 33 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2015.
All research outputs
#15,740,207
of 25,374,647 outputs
Outputs from Frontiers in immunology
#15,377
of 31,520 outputs
Outputs of similar age
#146,056
of 279,958 outputs
Outputs of similar age from Frontiers in immunology
#84
of 176 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,520 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,958 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.