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Fate Mapping of Dendritic Cells

Overview of attention for article published in Frontiers in immunology, May 2015
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Title
Fate Mapping of Dendritic Cells
Published in
Frontiers in immunology, May 2015
DOI 10.3389/fimmu.2015.00199
Pubmed ID
Authors

Mateusz Pawel Poltorak, Barbara Ursula Schraml

Abstract

Dendritic cells (DCs) are a heterogeneous group of mononuclear phagocytes with versatile roles in immunity. They are classified predominantly based on phenotypic and functional properties, namely their stellate morphology, expression of the integrin CD11c, and major histocompatibility class II molecules, as well as their superior capacity to migrate to secondary lymphoid organs and stimulate naïve T cells. However, these attributes are not exclusive to DCs and often change within inflammatory or infectious environments. This led to debates over cell identification and questioned even the mere existence of DCs as distinct leukocyte lineage. Here, we review experimental approaches taken to fate map DCs and discuss how these have shaped our understanding of DC ontogeny and lineage affiliation. Considering the ontogenetic properties of DCs will help to overcome the inherent shortcomings of purely phenotypic- and function-based approaches to cell definition and will yield a more robust way of DC classification.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Germany 1 <1%
France 1 <1%
Brazil 1 <1%
Unknown 153 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 25%
Researcher 28 18%
Student > Master 21 13%
Student > Bachelor 15 10%
Student > Doctoral Student 12 8%
Other 12 8%
Unknown 30 19%
Readers by discipline Count As %
Immunology and Microbiology 38 24%
Agricultural and Biological Sciences 35 22%
Biochemistry, Genetics and Molecular Biology 30 19%
Medicine and Dentistry 13 8%
Neuroscience 3 2%
Other 8 5%
Unknown 30 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2023.
All research outputs
#16,123,231
of 25,483,400 outputs
Outputs from Frontiers in immunology
#16,791
of 31,801 outputs
Outputs of similar age
#150,551
of 279,222 outputs
Outputs of similar age from Frontiers in immunology
#90
of 178 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,801 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,222 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 178 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.